Pattern Recognition of Longitudinal Trial Data with Nonignorable Missingness: An Empirical Case Study
Fang, Hua (Julia) ; Espy, Kimberly Andrews ; Rizzo, Maria L. ; Stopp, Christian ; Wiebe, Sandra A. ; Stroup, Walter W.
Citations
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Publication Date
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
Methods for identifying meaningful growth patterns of longitudinal trial data with both nonignorable intermittent and drop-out missingness are rare. In this study, a combined approach with statistical and data mining techniques is utilized to address the nonignorable missing data issue in growth pattern recognition. First, a parallel mixture model is proposed to model the nonignorable missing information from a real-world patient-oriented study and concurrently to estimate the growth trajectories of participants. Then, based on individual growth parameter estimates and their auxiliary feature attributes, a fuzzy clustering method is incorporated to identify the growth patterns. This case study demonstrates that the combined multi-step approach can achieve both statistical generality and computational efficiency for growth pattern recognition in longitudinal studies with nonignorable missing data.
Source
Int J Inf Technol Decis Mak. 2009 Sep 1;8(3):491-513. Link to article on publisher's site