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Pattern Recognition of Longitudinal Trial Data with Nonignorable Missingness: An Empirical Case Study

Fang, Hua (Julia)
Espy, Kimberly Andrews
Rizzo, Maria L.
Stopp, Christian
Wiebe, Sandra A.
Stroup, Walter W.
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Abstract

Methods for identifying meaningful growth patterns of longitudinal trial data with both nonignorable intermittent and drop-out missingness are rare. In this study, a combined approach with statistical and data mining techniques is utilized to address the nonignorable missing data issue in growth pattern recognition. First, a parallel mixture model is proposed to model the nonignorable missing information from a real-world patient-oriented study and concurrently to estimate the growth trajectories of participants. Then, based on individual growth parameter estimates and their auxiliary feature attributes, a fuzzy clustering method is incorporated to identify the growth patterns. This case study demonstrates that the combined multi-step approach can achieve both statistical generality and computational efficiency for growth pattern recognition in longitudinal studies with nonignorable missing data.

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Int J Inf Technol Decis Mak. 2009 Sep 1;8(3):491-513. Link to article on publisher's site

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DOI
10.1142/S0219622009003508
PubMed ID
20336179
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