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CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
Lian, Haiwei Li, Dun Zhou, Yun Landesman-Bollag, Esther Zhang, Guanglan Anderson, Nicole M. Tang, Kevin Charles Roderick, Justine E. Kelliher, Michelle A. Seldin, David C.
Lian, Haiwei
Li, Dun
Zhou, Yun
Landesman-Bollag, Esther
Zhang, Guanglan
Anderson, Nicole M.
Tang, Kevin Charles
Roderick, Justine E.
Kelliher, Michelle A.
Seldin, David C.
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UMass Chan Affiliations
Document Type
Letter to the Editor
Publication Date
2017-01-01
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Abstract
Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.
Source
Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
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DOI
10.3324/haematol.2016.154013
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PubMed ID
27758824
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Notes
Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.
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Copyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors.