A Nutrition-Longevity Tradeoff Enforced by Innate Immunity
Wani, Khursheed A Goswamy, Debanjan Irazoqui, Javier E
Wani, Khursheed A
Goswamy, Debanjan
Irazoqui, Javier E
Citations
Altmetric:
Student Authors
Faculty Advisor
Academic Program
Document Type
Response or Comment
Publication Date
2019-06-06
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
Dietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.
Source
Mol Cell. 2019 Jun 6;74(5):864-865. doi: 10.1016/j.molcel.2019.05.012. Link to article on publisher's site
Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1016/j.molcel.2019.05.012
Permanent Link to this Item
PubMed ID
31173721