Cutting edge: MHC class II-restricted killing in vivo during viral infection
Jellison, Evan Robert Kim, Sung-Kwon Welsh, Raymond M.
Jellison, Evan Robert
Kim, Sung-Kwon
Welsh, Raymond M.
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Student Authors
Evan Robert Jellison
Faculty Advisor
Academic Program
Immunology and Virology
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2005-01-07
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Abstract
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
Source
J Immunol. 2005 Jan 15;174(2):614-8.
Year of Medical School at Time of Visit
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DOI
10.4049/jimmunol.174.2.614
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PubMed ID
15634878