TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway
Girnius, Nomeda Davis, Roger J.
Girnius, Nomeda
Davis, Roger J.
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Student Authors
Faculty Advisor
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2016-02-08
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Abstract
Smac mimetics (SMs), a class of drugs that can promote tumor cell death, represent a potential therapeutic strategy for the treatment of cancer. In this issue of Cancer Cell, Lalaoui et al. (2016) report that SM efficacy can be potently increased by inhibition of the p38alpha MAPK/MK2 signaling pathway.
Source
Cancer Cell. 2016 Feb 8;29(2):131-3. doi: 10.1016/j.ccell.2016.01.008. Link to article on publisher's site
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DOI
10.1016/j.ccell.2016.01.008
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PubMed ID
26859448