Mohs micrographic surgery (MMS) is widely used to treat nonmelanoma skin cancer. The most frequent complication of MMS is surgical site infections (SSI), with incidences ranging from 0.07% to 4.34%. Variations among studies in the definition of SSI used may contribute to the wide range of rates reported. The Centers for Disease Control and Prevention (CDC) has defined SSI as occurring within 30 days of a procedure and meeting at least 1 of 4 characteristics, including purulent drainage, positive wound culture, clinical criteria, or diagnosis of SSI by the surgeon/attending physician. However, this definition is infrequently used in the literature. The lack of a consensus definition of SSI after MMS renders the true prevalence of SSI unknown, hindering the development of informed antibiotic and infection-control guidelines. Here, we sought to review the existing literature on infection rates after MMS and variations among the criteria for SSI reported.