Editorial on the Research Topic:Cell-to-cell communications in alcohol-associated, metabolic-related and viral liver diseases. The Research Topic “Cell-To-Cell Communications In Alcohol-Associated, Metabolic-Related And Viral Liver Diseases” proposed by the journal, Frontiers in Physiology has attracted articles on preclinical and clinical studies that were covered in three review articles and one original research manuscript. Overall, the goal of this topical collection is to provide a better understanding of the molecular mechanism(s) that cause the development and progression of alcohol-associated, metabolic-related, and viral liver diseases. Our hope is that the information in these articles could aid in identifying new biomarkers, therapeutic targets, and promising therapeutic agents that prevent, manage, or reverse disease progression. Here, we, as guest editors, provide a summary of all the articles published in this important issue.