For individuals coping with chronic illnesses such as HIV, spirituality and religion are often centrally important as patients face a unique array of existential challenges as a result of the diagnosis and management of the disease. It is critical for healthcare providers to be cognizant of the spiritual component of HIV/AIDS and to be knowledgeable regarding what the current literature base suggests in terms of addressing spirituality with patients. This Psychiatry Issue Brief provides an overview of the role of spirituality for individuals living with HIV, and offers recommendations for service providers.