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Mouse Study of Combined DNA/Protein COVID-19 Vaccine to Boost High Levels of Antibody and Cell Mediated Immune Responses

He, Qian
Liu, Shuying
Liang, Zhenglun
Lu, Shan
Cun, Wei
Mao, Qunyan
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Faculty Advisor
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UMass Chan Affiliations
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Accepted Manuscript
Publication Date
2022-11-25
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Abstract

­­­­­­In our previous studies, we showed the high immunogenicity of heterologous DNA prime, protein boost HIV vaccines in humans. More recently a combination DNA/Protein COVID-19 vaccine developed by us showed high immunogenicity and sterilizing protection in a non-human primate model against SARS-CoV-2 challenge. In the current study, we aim to test whether this combination DNA/Protein vaccine can also be used as a booster to other types of COVID-19 vaccines.

Source

He Q, Liu S, Liang Z, Lu S, Cun W, Mao Q. Mouse Study of Combined DNA/Protein COVID-19 Vaccine to Boost High Levels of Antibody and Cell Mediated Immune Responses. Emerg Microbes Infect. 2022 Nov 25:1-13. doi: 10.1080/22221751.2022.2152388. Epub ahead of print. PMID: 36426608.

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DOI
10.1080/22221751.2022.2152388
PubMed ID
36426608
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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.