Impact of Mismatched Detector-Blur Models on Ga SPECT Tumor Detection
Gifford, Howard C. ; King, Michael A
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Single photon emission computed tomography
Attenuation
Electromagnetic scattering
Particle scattering
Optical collimators
Degradation
Inverse problems
Neoplasms
Humans
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Bioimaging and Biomedical Optics
Biological and Chemical Physics
Nuclear
Nuclear Engineering
Radiology
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Abstract
The quality of SPECT images suffers from the effects of photon attenuation and scatter, and from distance-dependent collimator blur, and many researchers have shown the benefit of compensating for these degradations in the inverse problem. For this work, we examined how using an incorrect collimator-blur model affects the detection and localization of (67)Ga-avid lymphomas in simulated chest scans. In particular, we considered whether blur-overcompensation can enhance reconstructed images for purposes of localizing tumors. Variations in the correct linear model for medium-energy, parallel-hole collimators were compared by means of LROC studies with human and localizing model observers. Imaging data consisted of Simind projections of the MCAT phantom, and RBI reconstructions were performed. Our results indicate that tumor-detection performance is not improved by using a mismatched RC model. Reconstruction with increased RC requires more iterations, which leads to longer noise correlations. Our results also suggest a substantial observer insensitivity to the accuracy of the RC model.
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Gifford HC, King MA. Impact of Mismatched Detector-Blur Models on Ga SPECT Tumor Detection. IEEE Nucl Sci Symp Conf Rec (1997). 2007;6:4226-4229. doi: 10.1109/NSSMIC.2007.4437050. PMID: 19890463; PMCID: PMC2772205. Link to article on publisher's site