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Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells [preprint]

Lai, Rocky
Williams, Travis
Rakib, Tasfia
Lee, Jinhee
Behar, Samuel M
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Abstract

Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The distribution of M. tuberculosis among different cell types in the lung changes with the onset of T cell immunity when the dominant infected cellular niche shifts from alveolar to monocyte-derived macrophages (MDM). We hypothesize that changes in bacterial distribution among different cell types is driven by differences in T cell recognition of infected cells and their subsequent activation of antimicrobial effector mechanisms. We show that CD4 and CD8 T cells efficiently eliminate M. tuberculosis infection in alveolar macrophages, but they have less impact on suppressing infection in MDM, which may be a bacterial niche. Importantly, CD4 T cell responses enhance MDM recruitment to the lung. Thus, the outcome of infection depends on the interaction between the T cell subset and the infected cell; both contribute to the resolution and persistence of the infection.

Source

Lai R, Williams T, Rakib T, Lee J, Behar SM. Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells. bioRxiv [Preprint]. 2023 Dec 1:2023.11.29.569283. doi: 10.1101/2023.11.29.569283. PMID: 38076803; PMCID: PMC10705395.

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10.1101/2023.11.29.569283
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38076803
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This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.Attribution-NoDerivatives 4.0 International