The coronavirus disease 2019 (COVID-19) pandemic has influenced daily life in many ways, with significant effects on mental health and coping. Psychiatric nurses can leverage their expertise in supporting adaptive coping among individuals affected by the stressors of the pandemic. Literature related to common mental health stressors of the COVID-19 pandemic can guide nurses seeking to support clients. The current article uses the Roy Adaptation Model and a review of the literature to provide a framework for nurses to intervene and promote improved mental health across all settings. The role of nursing in promoting adaptation to COVID-19 mental health stressors is essential during and after the pandemic.