Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy
Shiu, Carlum Cunningham, Coleen K. Greenough, Thomas C. Muresan, Petronella Sanchez-Merino, Victor Carey, Vincent J. Jackson, J. Brooks Ziemniak, Carrie Fox, Lawrence Belzer, Marvin
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Abstract
In most human immunodeficiency virus type 1 (HIV-1)-infected individuals who achieve viral loads of /ml during highly active antiretroviral therapy (HAART), low levels of plasma virus remain detectable for years by ultrasensitive methods. The relative contributions of ongoing virus replication and virus production from HIV-1 reservoirs to persistent low-level viremia during HAART remain controversial. HIV-1 vaccination of HAART-treated individuals provides a model for examining low-level viremia, as immunizations may facilitate virus replication and sequence evolution. In a phase 1 trial of modified vaccinia virus Ankara/fowlpox virus-based HIV-1 vaccines in 20 HIV-infected young adults receiving HAART, we assessed the prevalence of low-level viremia and sequence evolution, using ultrasensitive viral load (
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J Virol. 2009 Oct;83(19):9731-42. Epub 2009 Jul 15. Link to article on publisher's website