Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya
Moormann, Ann M. Embury, Paula E. Opondo, J. Sumba, Peter Odada Ouma, J. H. Kazura, James W. John, Chandy C.
Moormann, Ann M.
Embury, Paula E.
Opondo, J.
Sumba, Peter Odada
Ouma, J. H.
Kazura, James W.
John, Chandy C.
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Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2004-08-17
Keywords
Adolescent
Adult
Aged
Altitude
Child
Child, Preschool
Endemic Diseases
Glucosephosphate Dehydrogenase Deficiency
Hemoglobin, Sickle
Humans
Infant
Infant, Newborn
Kenya
Malaria, Falciparum
Middle Aged
Polymorphism, Genetic
Prevalence
Residence Characteristics
Sickle Cell Trait
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Pediatrics
Adult
Aged
Altitude
Child
Child, Preschool
Endemic Diseases
Glucosephosphate Dehydrogenase Deficiency
Hemoglobin, Sickle
Humans
Infant
Infant, Newborn
Kenya
Malaria, Falciparum
Middle Aged
Polymorphism, Genetic
Prevalence
Residence Characteristics
Sickle Cell Trait
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Pediatrics
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
Source
Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. Link to article on publisher's site
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DOI
10.1016/S0035-9203(03)80010-X
Permanent Link to this Item
PubMed ID
15307413