Effect of erionite on the pleural mesothelium of the Fischer 344 rat

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dc.contributor.authorFraire, Armando E.
dc.contributor.authorGreenberg, S. Donald
dc.contributor.authorSpjut, Harlan J.
dc.contributor.authorDodson, Ronald F.
dc.contributor.authorWilliams, Glenn
dc.contributor.authorLach-Pasko, Ella
dc.contributor.authorRoggli, Victor L.
dc.contributor.departmentDepartment of Pathology
dc.date2022-08-11T08:09:56.000
dc.date.accessioned2022-08-23T16:49:46Z
dc.date.available2022-08-23T16:49:46Z
dc.date.issued1997-05-01
dc.date.submitted2008-06-18
dc.description.abstractOBJECTIVE: This study sought to assess the fibrogenic and carcinogenic potential of erionite (a fibrous zeolite) on the pleural mesothelium of the Fischer 344 rat (n = 24). DESIGN: The study was designed to examine rat pleural mesothelial changes by three independent observers at timed intervals, ranging from 1 to 480 days postinoculation using erionite from the Pine Valley, Nevada (USA) area. The mean length and width of the erionite fibers were 2.29 and 0.48 microns, respectively. Only microscopic observations made by majority (2/3) or unanimity (3/3) were accepted for final diagnosis. RESULTS: Pleural and lung tissue were available for examination in 21 of the 24 rats. Fibrosis, chronic inflammation, and foreign body reaction occurred in 6 of 21 rats. Mesothelial hyperplasia and dysplasia occurred in 9 and 3 of the 21 rats, respectively. A single mesothelioma was identified at 434 days in a rat that had gross nodular pleural lesions. CONCLUSIONS: The findings reported herein confirm the strong fibrogenic potential of erionite but are at variance with previous studies reporting much higher yields of mesothelioma. The reasons for the low yield of mesothelioma in this study are not known, but may be related to the study design, the strict criteria used for histopathologic diagnosis, and/or possible differences in erionite physicochemical properties, associated with its geographic distribution, most previous animal studies having used erionite from the Rome, Oregon (USA) area.
dc.identifier.citation<p>Chest. 1997 May;111(5):1375-80.</p>
dc.identifier.contextkey533144
dc.identifier.issn0012-3692 (Print)
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/431
dc.identifier.pmid9149597
dc.identifier.submissionpathoapubs/431
dc.identifier.urihttps://hdl.handle.net/20.500.14038/41527
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9149597&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1378/chest.111.5.1375
dc.source.issue5
dc.source.journaltitleChest
dc.source.pages1375-80
dc.source.volume111
dc.subjectEpithelium
dc.subjectHyperplasia
dc.subjectLung Diseases
dc.subjectMesothelioma
dc.subjectPleural Diseases
dc.subjectPleural Neoplasms
dc.subjectPleurisy
dc.subjectPneumonia
dc.subjectPulmonary Fibrosis
dc.subjectRats
dc.subjectZeolites
dc.titleEffect of erionite on the pleural mesothelium of the Fischer 344 rat
dc.typeJournal Article
dspace.entity.typePublication
html.description.abstract<p>OBJECTIVE: This study sought to assess the fibrogenic and carcinogenic potential of erionite (a fibrous zeolite) on the pleural mesothelium of the Fischer 344 rat (n = 24). DESIGN: The study was designed to examine rat pleural mesothelial changes by three independent observers at timed intervals, ranging from 1 to 480 days postinoculation using erionite from the Pine Valley, Nevada (USA) area. The mean length and width of the erionite fibers were 2.29 and 0.48 microns, respectively. Only microscopic observations made by majority (2/3) or unanimity (3/3) were accepted for final diagnosis. RESULTS: Pleural and lung tissue were available for examination in 21 of the 24 rats. Fibrosis, chronic inflammation, and foreign body reaction occurred in 6 of 21 rats. Mesothelial hyperplasia and dysplasia occurred in 9 and 3 of the 21 rats, respectively. A single mesothelioma was identified at 434 days in a rat that had gross nodular pleural lesions. CONCLUSIONS: The findings reported herein confirm the strong fibrogenic potential of erionite but are at variance with previous studies reporting much higher yields of mesothelioma. The reasons for the low yield of mesothelioma in this study are not known, but may be related to the study design, the strict criteria used for histopathologic diagnosis, and/or possible differences in erionite physicochemical properties, associated with its geographic distribution, most previous animal studies having used erionite from the Rome, Oregon (USA) area.</p>
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