Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography

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dc.contributor.authorLin, Honghuang
dc.contributor.authorKwan, Alan C
dc.contributor.authorCastro-Diehl, Cecilia
dc.contributor.authorShort, Meghan I
dc.contributor.authorXanthakis, Vanessa
dc.contributor.authorYola, Ibrahim M
dc.contributor.authorSalto, Gerran
dc.contributor.authorMitchell, Gary F
dc.contributor.authorLarson, Martin G
dc.contributor.authorVasan, Ramachandran S
dc.contributor.authorCheng, Susan
dc.contributor.departmentMedicine
dc.date.accessioned2025-01-15T16:37:12Z
dc.date.available2025-01-15T16:37:12Z
dc.date.issued2023-04-08
dc.description.abstractThe drivers of sexual dimorphism in heart failure phenotypes are currently poorly understood. Divergent phenotypes may result from differences in heritability and genetic versus environmental influences on the interplay of cardiac structure and function. To assess sex-specific heritability and genetic versus environmental contributions to variation and inter-relations between echocardiography traits in a large community-based cohort. We studied Framingham Heart Study participants of Offspring Cohort examination 8 (2005-2008) and Third Generation Cohort examination 1 (2002-2005). Five cardiac traits and six functional traits were measured using standardized echocardiography. Sequential Oligogenic Linkage Analysis Routines (SOLAR) software was used to perform singular and bivariate quantitative trait linkage analysis. In our study of 5674 participants (age 49 ± 15 years; 54% women), heritability for all traits was significant for both men and women. There were no significant differences in traits between men and women. Within inter-trait correlations, there were two genetic, and four environmental trait pairs with sex-based differences. Within both significant genetic trait pairs, men had a positive relation, and women had no significant relation. We observed significant sex-based differences in inter-trait genetic and environmental correlations between cardiac structure and function. These findings highlight potential pathways of sex-based divergent heart failure phenotypes.
dc.description.embargotypeNo embargo
dc.identifier.citationLin H, Kwan AC, Castro-Diehl C, Short MI, Xanthakis V, Yola IM, Salto G, Mitchell GF, Larson MG, Vasan RS, Cheng S. Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography. Sci Rep. 2023 Apr 8;13(1):5786. doi: 10.1038/s41598-023-32577-6. PMID: 37031215; PMCID: PMC10082757.
dc.identifier.doi10.1038/s41598-023-32577-6
dc.identifier.issn2045-2322
dc.identifier.pii10.1038/s41598-023-32577-6
dc.identifier.pmid37031215
dc.identifier.urihttps://hdl.handle.net/20.500.14038/54065
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.relation.urlhttps://doi.org/10.1038/s41598-023-32577-6
dc.rightsOpen Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/. © The Author(s) 2023
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.beginpage5786
dc.source.countryEngland
dc.source.issue1
dc.source.journaltitleScientific reports
dc.source.volume13
dc.subjectCardiology
dc.subjectCardiovascular genetics
dc.subjectHeart failure
dc.titleSex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography
dc.typeJournal Article
dspace.entity.typePublication
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