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Catenin' on to nucleic acid sensing

Rathinam, Vijay A.K.
; 
Sharma, Shrutie
; 
Fitzgerald, Katherine A
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Authors
Rathinam, Vijay A.K.
Sharma, Shrutie
Fitzgerald, Katherine A
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal Article
Publication Date
2010-05-21
Keywords
Catenins
 Humans
 Immunity, Innate
 Interferon Regulatory Factor-3
 Interferon Type I
 Listeria monocytogenes
 Protein-Serine-Threonine Kinases
 RNA-Binding Proteins
 Signal Transduction
 Vesicular Stomatitis
 Immunology and Infectious Disease
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UMass Chan Faculty and Researcher Publications
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Link to Full Text
http://dx.doi.org/10.1038/ni0610-466
Abstract

Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.

Source

Nat Immunol. 2010 Jun;11(6):466-8. Link to article on publisher's site

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DOI
10.1038/ni0610-466
Permanent Link to this Item
https://hdl.handle.net/20.500.14038/35214
PubMed ID
20485273
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