Obesity Notches up fatty liver
Czech, Michael P.
Czech, Michael P.
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2013-08-06
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Abstract
Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.
Source
Nat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. Link to article on publisher's site
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DOI
10.1038/nm.3293
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PubMed ID
23921741