The MutS C terminus is essential for mismatch repair activity in vivo
Calmann, Melissa A. Nowosielska, Anetta Marinus, Martin G.
Calmann, Melissa A.
Nowosielska, Anetta
Marinus, Martin G.
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Journal Article
Publication Date
2005-09-15
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Abstract
An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.
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J Bacteriol. 2005 Sep;187(18):6577-9. Link to article on publisher's site
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DOI
10.1128/JB.187.18.6577-6579.2005
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PubMed ID
16159793