As we head into the third year of the COVID-19 pandemic and second year of COVID-19 vaccine availability, cutaneous reactions to COVID-19 and various COVID-19 vaccine types have become increasingly reported and categorized. The American Academy of Dermatology and International League of Dermatological Societies have collaborated to create a COVID-19 dermatology registry to record cases of cutaneous reactions associated with either the infection or the vaccine. The most common cutaneous reactions seen after COVID-19 vaccination are local injection site reactions. There have been limited reports of vitiligo after COVID-19 vaccination to date, and literature remains scarce. Clinical trials of COVID-19 vaccines did not report any cases of new-onset vitiligo after mRNA vaccines; however, there was 1 case after adenovirus-based AstraZeneca vaccination among the cutaneous adverse events noted after vaccination. Here, we present a case of a patient developing vitiligo specifically on the arm at the site of injection after COVID-19 vaccination.