GBPs take AIM at Francisella
Fitzgerald, Katherine A Rathinam, Vijay A. K.
Fitzgerald, Katherine A
Rathinam, Vijay A. K.
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UMass Chan Affiliations
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Journal Article
Publication Date
2015-05-01
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Abstract
Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
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Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. Link to article on publisher's site
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DOI
10.1038/ni.3144
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PubMed ID
25898190