Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk
Ma, Yunsheng Culver, Annie L. Rossouw, Jacques E. Olendzki, Barbara C. Merriam, Philip A. Lian, Bill Ockene, Ira S.
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Abstract
Purpose of review: The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review.
Recent findings: The literature contains reports of new-onset diabetes associated with statin use. While many studies do not report sex-specific results, there is evidence indicating the risk to benefit ratio may vary by gender. However, the absolute effects are not clear because women have historically been under-represented in clinical trials.
Summary: A review of the literature indicates that the cardiovascular benefits of statins appear to outweigh the risk for statin-related diabetes. However, the effect may depend upon baseline diabetes risk, dose, and statin potency. Rigorous, long-term studies focused on the risks and benefits of statins in women are unavailable to sort for gender-specific differences. Until this changes, individualized attention to risk assessment, and strong prevention with lifestyle changes must prevail.
Source
Ther Adv Cardiovasc Dis. 2013 Feb;7(1):41-4. doi: 10.1177/1753944712468499. Link to article on publisher's site