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The risk and consequences of breakthrough SARS-CoV-2 infection in solid organ transplant recipients relative to non-immunosuppressed controls

Vinson, Amanda J
Anzalone, Alfred J
Sun, Jing
Dai, Ran
Agarwal, Gaurav
Lee, Stephen B
French, Evan
Olex, Amy
Ison, Michael G
Mannon, Roslyn B
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Abstract

Clinical outcomes in solid organ transplant (SOT) recipients with breakthrough COVID (BTCo) after two doses of mRNA vaccination compared to the non-immunocompromised/immunosuppressed (ISC) general population, are not well described. In a cohort of adult patients testing positive for COVID-19 between December 10, 2020 and April 4, 2022, we compared the cumulative incidence of BTCo in a non-ISC population to SOT recipients (overall and by organ type) using the National COVID Cohort Collaborative (N3C) including data from 36 sites across the United States. We assessed the risk of complications post-BTCo in vaccinated SOT recipients versus SOT with unconfirmed vaccination status (UVS) using multivariable Cox proportional hazards and logistic regression. BTCo occurred in 4776 vaccinated SOT recipients over a median of 149 days (IQR 99-233), with the highest cumulative incidence in heart recipients. The relative risk of BTCo was greatest in SOT recipients (relative to non-ISC) during the pre-Delta period (HR 2.35, 95% CI 1.80-3.08). The greatest relative benefit with vaccination for both non-ISC and SOT cohorts was in BTCo mortality (HR 0.37, 95% CI 0.36-0.39 for non-ISC; HR 0.67, 95% 0.57-0.78 for SOT relative to UVS). While the relative benefit of vaccine was less in SOT than non-ISC, SOT patients still exhibited significant benefit with vaccination.

Source

Vinson AJ, Anzalone AJ, Sun J, Dai R, Agarwal G, Lee SB, French E, Olex A, Ison MG, Mannon RB; N3C consortium. The risk and consequences of breakthrough SARS-CoV-2 infection in solid organ transplant recipients relative to non-immunosuppressed controls. Am J Transplant. 2022 Oct;22(10):2418-2432. doi: 10.1111/ajt.17117. Epub 2022 Jun 20. PMID: 35674237; PMCID: PMC9348256.

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DOI
10.1111/ajt.17117
PubMed ID
35674237
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Funding and Acknowledgements
The UMass Center for Clinical and Translational Science (UMCCTS), UL1TR001453, provided data for this study.
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© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.
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