Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence

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dc.contributor.authorZabik, Nicole L
dc.contributor.authorFlook, Elizabeth A
dc.contributor.authorFeola, Brandee
dc.contributor.authorBenningfield, Margaret M
dc.contributor.authorSilveri, Marisa M
dc.contributor.authorWinder, Danny G
dc.contributor.authorBlackford, Jennifer Urbano
dc.contributor.departmentNeurobiologyen_US
dc.contributor.departmentWinder Lab
dc.date.accessioned2024-09-25T14:03:26Z
dc.date.available2024-09-25T14:03:26Z
dc.date.issued2024-08-24
dc.description.abstractBackground: Anxiety during early alcohol abstinence, likely resulting from neural changes caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show heightened activation during early abstinence in the bed nucleus of the stria terminalis (BNST)-a neural hub for anxiety-and its extended anxiety-related corticolimbic network. Despite the clinical importance of early abstinence, few studies investigate the underlying neural mechanisms. Methods: To address this gap, we investigated brain function in early alcohol abstinence (EA = 20, 9 women) relative to controls (HC = 20, 11 women) using an unpredictable threat task shown to engage the BNST and corticolimbic brain regions involved in anxiety and alcohol use disorder (AUD). Group, anxiety, and sex were predictors used to determine whole-brain activation and BNST functional connectivity. Results: We found widespread interactions of group × anxiety and group × anxiety × sex for both activation and BNST connectivity during unpredictable threat. In the EA group, higher anxiety was correlated with activation in the BNST, rostral anterior cingulate cortex (ACC), insula (men only), and dorsal ACC (men only). In the HC group, higher anxiety was negatively correlated with activation in the BNST, nucleus accumbens, thalamus, and insula (men only). For connectivity, anxiety was positively correlated in EA and negatively correlated in HC, between the BNST and the amygdala, ventromedial prefrontal cortex (PFC), and dorsomedial PFC; EA men showed stronger BNST-vmPFC connectivity than HC men. Conclusions: These novel findings provide preliminary evidence for alterations in the BNST and anxiety-related corticolimbic brain regions in early alcohol abstinence, adding to growing literature in humans supporting the BNST's role in anxiety and sex-dependent effects of chronic alcohol use.en_US
dc.identifier.citationZabik NL, Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU. Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence. Alcohol Clin Exp Res (Hoboken). 2024 Aug 24. doi: 10.1111/acer.15407. Epub ahead of print. PMID: 39180622.en_US
dc.identifier.doi10.1111/acer.15407en_US
dc.identifier.eissn2993-7175
dc.identifier.journalAlcohol, clinical & experimental research
dc.identifier.pmid39180622
dc.identifier.urihttps://hdl.handle.net/20.500.14038/53811
dc.language.isoen
dc.relation.ispartofAlcohol, Clinical and Experimental Researchen_US
dc.relation.urlhttps://doi.org/10.1111/acer.15407en_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2024 The Author(s). Alcohol, Clinical and Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.journaltitleAlcohol, clinical & experimental research
dc.subjectabstinenceen_US
dc.subjectbed nucleus of the stria terminalisen_US
dc.subjectsex differencesen_US
dc.subjectunpredictable threaten_US
dc.titleBed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinenceen_US
dc.typeJournal Articleen_US
dspace.entity.typePublication
refterms.dateFOA2024-09-25T14:03:27Z
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