Differential vulnerability of thalamic nuclei in multiple sclerosis
Blyau, Simon Koubiyr, Ismail Saranathan, Manojkumar Coupé, Pierrick Deloire, Mathilde Charré-Morin, Julie Saubusse, Aurore Zhang, Bei Rutt, Brian Dousset, Vincent
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Abstract
Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS).
Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile.
Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group.
Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.
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Blyau S, Koubiyr I, Saranathan M, Coupé P, Deloire M, Charré-Morin J, Saubusse A, Zhang B, Rutt B, Dousset V, Brochet B, Ruet A, Tourdias T. Differential vulnerability of thalamic nuclei in multiple sclerosis. Mult Scler. 2023 Feb;29(2):295-300. doi: 10.1177/13524585221114247. Epub 2022 Aug 12. PMID: 35959722.