Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study

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dc.contributor.authorZammitti, Christopher
dc.contributor.authorTisminetzky, Mayra
dc.contributor.authorMehawej, Jordy
dc.contributor.authorAbu, Hawa O
dc.contributor.authorMiozzo, Ruben
dc.contributor.authorGore, Joel M
dc.contributor.authorLessard, Darleen M
dc.contributor.authorBamgbade, Benita A
dc.contributor.authorYarzebski, Jorge
dc.contributor.authorGurwitz, Jerry H
dc.contributor.authorGoldberg, Robert J.
dc.contributor.departmentBiostatistics and Health Services Researchen_US
dc.contributor.departmentMedicineen_US
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US
dc.contributor.departmentT.H. Chan School of Medicineen_US
dc.contributor.studentChristopher Zammitti
dc.date.accessioned2024-04-26T15:24:45Z
dc.date.available2024-04-26T15:24:45Z
dc.date.issued2024-03-27
dc.description.abstractBackground: Multiple chronic conditions (MCCs) are common in patients hospitalized with acute myocardial infarction (AMI). We examined the association of 12 MCCs with the risk of a 30-day hospital readmission and/or dying within one year among those discharged from the hospital after an AMI. We also examined the five most prevalent pairs of chronic conditions in this population and their association with the principal study endpoints. Methods: The study population consisted of 3,294 adults hospitalized with a confirmed AMI at the three major medical centers in central Massachusetts on an approximate biennial basis between 2005 and 2015. Patients were categorized as ≤1, 2-3, and ≥4 chronic conditions. Results: The median age of the study population was 67.9 years, 41.6% were women, and 15% had ≤1, 32% had 2-3, and 53% had ≥4 chronic conditions. Patients with ≥4 conditions tended to be older, had a longer hospital stay, and received fewer cardiac interventional procedures. There was an increased risk for being rehospitalized during the subsequent 30 days according to the presence of MCCs, with the highest risk for those with ≥4 conditions. There was an increased, but attenuated, risk for dying during the next year according to the presence of MCCs. Individuals with diabetes/hypertension and those with heart failure/chronic kidney disease were at particularly high risk for developing the principal study outcomes. Conclusion: Development of guidelines that include complex patients, particularly those with MCCs and those at high risk for adverse short/medium term outcomes, remain needed to inform best treatment practices.en_US
dc.identifier.citationZammitti C, Tisminetzky M, Mehawej J, Abu HO, Miozzo R, Gore JM, Lessard D, Bamgbade BA, Yarzebski J, Gurwitz JH, Goldberg RJ. Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study. J Multimorb Comorb. 2024 Mar 27;14:26335565241242279. doi: 10.1177/26335565241242279. PMID: 38549712; PMCID: PMC10976488.en_US
dc.identifier.doi10.1177/26335565241242279en_US
dc.identifier.eissn2633-5565
dc.identifier.journalJournal of multimorbidity and comorbidity
dc.identifier.pmid38549712
dc.identifier.urihttps://hdl.handle.net/20.500.14038/53300
dc.language.isoenen_US
dc.relation.ispartofJournal of Multimorbidity and Comorbidityen_US
dc.relation.urlhttps://doi.org/10.1177/26335565241242279en_US
dc.rightsCopyright © The Author(s) 2024. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).; Attribution-NonCommercial 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.source.beginpage26335565241242279
dc.source.countryEngland
dc.source.endpage
dc.source.journaltitleJournal of multimorbidity and comorbidity
dc.source.volume14
dc.subjectMyocardial infarctionen_US
dc.subjectchronic conditionsen_US
dc.titleShort and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack studyen_US
dc.typeJournal Articleen_US
dspace.entity.typePublication
refterms.dateFOA2024-04-26T15:24:47Z
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