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A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1

Bicker, Kevin L.
Obianyo, Obiamaka
Rust, Heather L.
Thompson, Paul R
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Abstract

The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity.

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Mol Biosyst. 2011 Jan;7(1):48-51. doi: 10.1039/c0mb00015a. Link to article on publisher's site. Epub 2010 Jul 6.

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10.1039/c0mb00015a
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At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.

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