Loading...
A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1
Bicker, Kevin L. ; Obianyo, Obiamaka ; Rust, Heather L. ; Thompson, Paul R
Bicker, Kevin L.
Obianyo, Obiamaka
Rust, Heather L.
Thompson, Paul R
Citations
Altmetric:
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2011-01-01
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity.
Source
Mol Biosyst. 2011 Jan;7(1):48-51. doi: 10.1039/c0mb00015a. Link to article on publisher's site. Epub 2010 Jul 6.
Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1039/c0mb00015a
Permanent Link to this Item
PubMed ID
Other Identifiers
Notes
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.