A systematic scoping review of research published between 2000 and 2020 on employment of people with disabilities, that was funded by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR), was conducted by CeKTER researchers. All papers comparing people with disabilities to those without were excluded from the systematic scoping review. Among over 100 publications reviewed there was a wide and very disparate array of findings with numerous variables used and varying research questions. This result belies summative findings. There are numerous ways of organizing the disparate findings. This brief is part of a series of findings from CeKTER's systematic scoping review. In this brief we report on findings about a range of health-related determinants impacting the employment of people with disabilities, including disability characteristics, health challenges, and lifestyle related determinants. Please note that all comparisons are always about corresponding peers with disabilities.