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Seizure as Presenting Symptom of Multisystem Inflammatory Syndrome in Children

D'Ambrosio, Eleonora S
Gauguet, Stefanie
Miller, Christine
McMahon, Erin
Driscoll, Christopher
Mohanty, Mugdha
Guggina, Thomas
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Case Report
Publication Date
2023-07-08
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Abstract

We describe the case of a 13-year-old girl who presented with a new-onset seizure and fever and subsequently developed severe cardiac dysfunction, coronary artery dilation, and shock due to the surprising diagnosis of multisystem inflammatory syndrome in children (MIS-C). Although the clinical entity we now call MIS-C was first mentioned in the medical literature in April 2020, the full picture of this disease process is still evolving. Neurologic involvement has been described in cases with MIS-C; however, seizures are not a typical presenting symptom. Additionally, because children infected with SARS-CoV-2 are often asymptomatic, a documented preceding COVID-19 infection might not be available to raise suspicion of MIS-C early on. Febrile seizures, meningitis, and encephalitis are childhood illnesses that pediatricians are generally familiar with, but associating these clinical pictures with MIS-C is uncommon. Given the possibility of rapid clinical cardiogenic decline, as seen in our patient, a prompt diagnosis and appropriate monitoring and treatment are of utmost importance. This case report aims to raise awareness that new-onset seizures with fevers can be early or the first presenting symptoms in children with MIS-C, and further workup and close monitoring may be required.

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D'Ambrosio ES, Gauguet S, Miller C, McMahon E, Driscoll C, Mohanty M, Guggina T. Seizure as Presenting Symptom of Multisystem Inflammatory Syndrome in Children. Case Rep Infect Dis. 2023 Jul 8;2023:3581310. doi: 10.1155/2023/3581310. PMID: 37456213; PMCID: PMC10349669.

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10.1155/2023/3581310
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37456213
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Copyright © 2023 Eleonora S. D’Ambrosio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Attribution 4.0 International