Mucosal closure techniques are the backbone of interventional endoscopy, requiring focused and dedicated development. We present a novel closure technique that is easily applicable, economical, and effective for large mucosal defects.

An 85-year-man underwent gastric endoscopic submucosal dissection for adenocarcinoma of the stomach, which resulted in an ulcer measuring around 35 × 25 mm in size ([Fig. 1]), and this was closed using the novel “CLiPS technique” ([Video 1]).