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Inferring ADR causality by predicting the Naranjo Score from Clinical Notes

Singh Rawat, Bhanu Pratap
Jagannatha, Abhyuday
Liu, Feifan
Yu, Hong
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Abstract

Clinical judgment studies are an integral part of drug safety surveillance and pharmacovigilance frameworks. They help quantify the causal relationship between medication and its adverse drug reactions (ADRs). To conduct such studies, physicians need to review patients' charts manually to answer Naranjo questionnaire(1). In this paper, we propose a methodology to automatically infer causal relations from patients' discharge summaries by combining the capabilities of deep learning and statistical learning models. We use Bidirectional Encoder Representations from Transformers (BERT)(2) to extract relevant paragraphs for each Naranjo question and then use a statistical learning model such as logistic regression to predict the Naranjo score and the causal relation between the medication and an ADR. Our methodology achieves a macro-averaged f1-score of 0.50 and weighted f1-score of 0.63.

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Rawat BPS, Jagannatha A, Liu F, Yu H. Inferring ADR causality by predicting the Naranjo Score from Clinical Notes. AMIA Annu Symp Proc. 2021 Jan 25;2020:1041-1049. PMID: 33936480; PMCID: PMC8075501.

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33936480
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Copyright ©2020 AMIA. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose.
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