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Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic

Muhuri, Manish
; 
Gao, Guangping
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Authors
Muhuri, Manish
Gao, Guangping
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Li Weibo Institute for Rare Diseases Research
 Department of Microbiology and Physiological Systems
 Horae Gene Therapy Center
Document Type
Journal Article
Publication Date
2020-10-06
Keywords
COVID-19
 pandemic
 vaccine
 recombinant receptor-binding domain
 RBD
 SARS-CoV-2 Spike Protein
 Immunology of Infectious Disease
 Immunopathology
 Immunoprophylaxis and Therapy
 Immunotherapy
 Infectious Disease
 International Public Health
 Microbiology
 Therapeutics
 Virus Diseases
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COVID-19 Publications by UMass Chan Authors
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Abstract

A recent report by Yang et al. published in Nature reported a recombinant vaccine utilizing recombinant receptor-binding domain (RBD) of SARS-CoV-2 Spike Protein.This vaccine candidate successfully induced potent functional antibody responses in the immunized mice, rabbits, and non-human primates. The study highlights the critical role of the immunogenicity of the RBD domain upon SARS-CoV-2 infection and the alternate vaccine designs that could serve as effective prophylactics against the pandemic.

Source

Muhuri M, Gao G. Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic. Signal Transduct Target Ther. 2020 Oct 6;5(1):222. doi: 10.1038/s41392-020-00317-1. PMID: 33024086; PMCID: PMC7537771. Link to article on publisher's site

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DOI
10.1038/s41392-020-00317-1
Permanent Link to this Item
https://hdl.handle.net/20.500.14038/27350
PubMed ID
33024086
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Copyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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