The Career Flexibility for Biomedical Faculty of Today and Tomorrow conference held March 14-15, 2015 in Boston grew out of the ACE/Sloan proposal from the University of Massachusetts Medical School. The seven medical schools receiving Alfred P. Sloan Awards for Faculty Career Flexibility, working in collaboration with the American Council on Education (ACE) and the New England Network for Faculty Affairs (NENFA), shared this passion and together developed and organized the conference to disseminate and expand the work being done in this area. The goal was to conduct a national conference to identify and disseminate generalizable principles, strategies, interventions, and tools that can be used to advance career flexibility in medical schools throughout the career lifecycle from recruitment through retirement.