Publication

Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation

Tay, Joyce
Hodgman, Rebecca
Sarkissian, Madathia
Richter, Joel D.
Citations
Altmetric:
Authors
Tay, Joyce
Hodgman, Rebecca
Sarkissian, Madathia
Richter, Joel D.
Student Authors
Faculty Advisor
Academic Program
Document Type
Journal Article
Publication Date
2003-06-20
Keywords
Subject Area
Embargo Expiration Date
Abstract

CPEB is an mRNA-binding protein that stimulates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Thr 171 (species-dependent). Disruption of the CPEB gene in mice causes an arrest of oogenesis at embryonic day 16.5 (E16.5), when most oocytes are in pachytene of prophase I. Here, we show that CPEB undergoes Thr 171 phosphorylation at E16.5, but dephosphorylation at the E18.5, when most oocytes are entering diplotene. Although phosphorylation is mediated by the kinase aurora, the dephosphorylation is due to the phosphatase PP1. The temporal control of CPEB phosphorylation suggests a mechanism in which CPE-containing mRNA translation is stimulated at pachytene and metaphase I.

Source

Genes Dev. 2003 Jun 15;17(12):1457-62. Link to article on publisher's site

Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1101/gad.1071403
PubMed ID
12815066
Other Identifiers
Notes
Funding and Acknowledgements
Corresponding Author
Related Resources
Related Resources
Repository Citation
Rights
Distribution License