Translocation mapping exposes the risky lifestyle of B cells
McCord, Rachel Patton Dekker, Job
McCord, Rachel Patton
Dekker, Job
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Journal Article
Publication Date
2011-09-30
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Abstract
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
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Cell. 2011 Sep 30;147(1):20-2. Link to article on publisher's site
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DOI
10.1016/j.cell.2011.09.005
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PubMed ID
21962501