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Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia
Shmukler, Boris E. Huston, Nicholas C. Thon, Jonathan N. Ni, Chih-Wen Kourkoulis, George Lawson, Nathan D. Paw, Barry H. Alper, Seth L.
Shmukler, Boris E.
Huston, Nicholas C.
Thon, Jonathan N.
Ni, Chih-Wen
Kourkoulis, George
Lawson, Nathan D.
Paw, Barry H.
Alper, Seth L.
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UMass Chan Affiliations
Document Type
Letter to the Editor
Publication Date
2015-12-01
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e483.full.pdf
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Abstract
We have now examined the erythroid phenotype in this zebrafish strain carrying a ZFN genomic knockout of piezo1. Genotyping was performed as previously described. In contrast to the anemic phenotype observed in zebrafish subjected to morpholino knockdown of piezo, the genomic ZFN knockout of piezo1 did not segregate either with anemia in the 3-dpf embryo or with dysmorphic erythrocyte morphology in the adult fish.
Source
Haematologica. 2015 Dec;100(12):e483-5. doi: 10.3324/haematol.2015.132449. Epub 2015 Aug 20. Link to article on publisher's site
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DOI
10.3324/haematol.2015.132449
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PubMed ID
26294733
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<p>Haematologica is an Open Access Publication according to the Budapest Open Access Initiative (per http://www.haematologica.org/about-the-journal).</p>