Glia instruct developmental neuronal remodeling through TGF-beta signaling
Awasaki, Takeshi ; Huang, Ya-ling ; O'Connor, Michael B. ; Lee, Tzumin
Awasaki, Takeshi
Huang, Ya-ling
O'Connor, Michael B.
Lee, Tzumin
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Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2011-06-19
Keywords
Animals
Animals, Genetically Modified
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
MicroRNAs
*Models, Neurological
Mushroom Bodies
Mutation
Neurogenesis
Neuroglia
RNA, Double-Stranded
Signal Transduction
Transforming Growth Factor beta
Neuroscience and Neurobiology
Animals, Genetically Modified
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
MicroRNAs
*Models, Neurological
Mushroom Bodies
Mutation
Neurogenesis
Neuroglia
RNA, Double-Stranded
Signal Transduction
Transforming Growth Factor beta
Neuroscience and Neurobiology
Subject Area
Collections
Embargo Expiration Date
Link to Full Text
Abstract
We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
Source
Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. Link to article on publisher's site
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DOI
10.1038/nn.2833
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PubMed ID
21685919