Publication

Glia instruct developmental neuronal remodeling through TGF-beta signaling

Awasaki, Takeshi
Huang, Ya-ling
O'Connor, Michael B.
Lee, Tzumin
Embargo Expiration Date
Abstract

We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

Source

Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. Link to article on publisher's site

Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1038/nn.2833
PubMed ID
21685919
Other Identifiers
Notes
Funding and Acknowledgements
Corresponding Author
Related Resources
Related Resources
Repository Citation
Rights
Distribution License