Management of acute coronary syndromes (ACS) involves a series of diagnostic and therapeutic decisions and can include a variety of invasive and noninvasive interventions. The potential risks and benefits of these interventions, especially in specific patient populations, remain uncertain. The purpose of the Global Registry of Acute Coronary Events (GRACE) is to gather data about the management and outcome of ACS in a robust, multinational population and to use these data to improve the care and management of patients with ACS.