Initial experience with volumetric IMRT (RapidArc) for intracranial stereotactic radiosurgery
Mayo, Charles S. Addesa, Anthony FitzGerald, Thomas J Ding, Linda Kadish, Sidney P. Moser, Richard P.
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Abstract
PURPOSE: Initial experience with delivering frameless stereotactic radiotherapy (SRT) using volumetric intensity-modulated radiation therapy (IMRT) delivered with RapidArc is presented.
METHODS AND MATERIALS: Treatment details for 12 patients (14 targets) with a mean clinical target volume (CTV) of 12.8 +/- 4.0 cm(3) were examined. Dosimetric indices for conformality, homogeneity, and dose gradient were calculated and compared with published results for other frameless, intracranial SRT techniques, including CyberKnife, TomoTherapy, and static-beam IMRT. Statistics on setup and treatment times and per patient dose validations were examined.
RESULTS: Dose indices compared favorably with other techniques. Mean conformality, gradient, and homogeneity index values were 1.10 +/- 0.11, 64.9 +/- 14.1, 1.083 +/- 0.026, respectively. Median treatment times were 4.8 +/- 1.7 min.
CONCLUSION: SRT using volumetric IMRT is a viable alternative to other techniques and enables short treatment times. This is anticipated to have a positive impact on radiobiological effect and for facilitating wider use of SRT.
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Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1457-66. doi: 10.1016/j.ijrobp.2009.10.005. Epub 2010 Mar 6. Link to article on publisher's site