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Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

Rodriguez-Rodriguez, Aurora
Shuvaev, Sergey
Rotile, Nicholas
Jones, Chloe M.
Probst, Clemens K.
Dos Santos Ferreira, Diego
Graham-O Regan, Katherine
Boros, Eszter
Knipe, Rachel S.
Griffith, Jason W.
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Abstract

An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.

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ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site

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10.1021/acssensors.9b01010
PubMed ID
31397156
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