Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control
Wood, Mollie E. ; Lapane, Kate L ; van Gelder, Marleen M. H. J. ; Rai, Dheeraj ; Nordeng, Hedvig M. E.
Wood, Mollie E.
Lapane, Kate L
van Gelder, Marleen M. H. J.
Rai, Dheeraj
Nordeng, Hedvig M. E.
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Faculty Advisor
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2017-10-17
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Abstract
Understanding the safety of medication use during pregnancy relies on observational studies: However, confounding in observational studies poses a threat to the validity of estimates obtained from observational data. Newer methods, such as marginal structural models and propensity calibration, have emerged to deal with complex confounding problems, but these methods have seen limited uptake in the pregnancy medication literature. In this article, we provide an overview of newer advanced methods for confounding control and show how these methods are relevant for pregnancy medication safety studies.
Source
Pharmacoepidemiol Drug Saf. 2017 Oct 17. doi: 10.1002/pds.4336. [Epub ahead of print] Link to article on publisher's site
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DOI
10.1002/pds.4336
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PubMed ID
29044735