Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3)
Qaseem, Amir Obley, Adam J Yost, Jennifer Abraham, George M Andrews, Rebecca A Jokela, Janet A Miller, Matthew C Humphrey, Linda L Humphrey, Linda L Obley, Adam J
Authors
Obley, Adam J
Yost, Jennifer
Abraham, George M
Andrews, Rebecca A
Jokela, Janet A
Miller, Matthew C
Humphrey, Linda L
Humphrey, Linda L
Obley, Adam J
Haeme, Ray
Krain, Alysa
Poonacha, Thejaswi
Saini, Sameer D
Wilt, Timothy J
Carroll, Kate
Etxeandia-Ikobaltzeta, Itziar
Harrod, Curtis S
Qaseem, Amir
Shamliyan, Tatyana
Vigna, Chelsea
Yost, Jennifer
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Publication Date
Keywords
Subject Area
Collections
Embargo Expiration Date
Link to Full Text
Abstract
DESCRIPTION: The American College of Physicians (ACP) maintains living, rapid practice points on antiviral treatment in the outpatient setting for COVID-19.
METHODS: The Population Health and Medical Science Committee (PHMSC) developed this version 3 based on evidence from a focused update of a living, rapid review conducted by the ACP Center for Evidence Reviews at Cochrane Austria. This version addresses the SARS-CoV-2 Omicron variant and reaffirms previous practice points on the use of antiviral treatments of confirmed COVID-19 in unvaccinated or vaccinated and symptomatic patients in the outpatient setting.
RETIREMENT FROM LIVING STATUS: The PHMSC is retiring this topic from living status considering that this update and previous surveillance have not yielded important changes to the practice points.
Source
Qaseem A, Obley AJ, Yost J, Abraham GM, Andrews RA, Jokela JA, Miller MC, Humphrey LL; Population Health and Medical Science Committee of the American College of Physicians; Humphrey LL, Obley AJ, Haeme R, Krain A, Poonacha T, Saini SD, Wilt TJ, Carroll K, Etxeandia-Ikobaltzeta I, Harrod CS, Qaseem A, Shamliyan T, Vigna C, Yost J. Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3). Ann Intern Med. 2026 Feb 10. doi: 10.7326/ANNALS-25-03766. Epub ahead of print. PMID: 41662713.