Time trends in medication use and expenditures in older patients with rheumatoid arthritis
Harrold, Leslie R ; Peterson, Daniel J. ; Beard, Ashley J. ; Gurwitz, Jerry H. ; Briesacher, Becky A.
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Keywords
Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Antirheumatic Agents
Arthritis, Rheumatoid
*Drug Costs
Drug Prescriptions
Female
Health Expenditures
Humans
Immunoglobulin G
Male
Medicare Part B
Medicare Part D
Receptors, Tumor Necrosis Factor
Sampling Studies
Time Factors
United States
Geriatrics
Health Services Research
Pharmacy and Pharmaceutical Sciences
Primary Care
Rheumatology
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Abstract
BACKGROUND: We sought to examine how expansions in insurance coverage of nonbiologic and biologic disease-modifying antirheumatic drugs affected the access, costs, and health status of older patients with rheumatoid arthritis.
METHODS: We identified a nationally representative sample of older adults with rheumatoid arthritis in the 2000-2006 Medicare Current Beneficiary Survey (unweighted n=1051). We examined changes in disease-modifying antirheumatic drug use, self-reported health status, functional status (activities of daily living), and total costs and out-of-pocket costs for medical care and prescription drugs. Tests for time trends were conducted using weighted regressions.
RESULTS: Between 2000 and 2006, the proportion of older adults with rheumatoid arthritis who received biologics tripled (4.6% vs 13.2%, P=.01), whereas the proportion of people who used a nonbiologic did not change. During the same period, the proportion of older patients with rheumatoid arthritis rating their health as excellent/good significantly increased (43.0% in 2000 to 55.6% in 2006; P=.015). Significant improvements occurred in activities of daily living measures of functional status. Total prescription drug costs (in 2006 US dollars) increased from $2645 in 2000 to $4685 in 2006, P=.0001, whereas out-of-pocket prescription costs remained constant ($842 in 2000 vs $832 in 2006; P=.68). Total medical costs did not significantly increase ($16,563 in 2000 vs $19,510 in 2006; P=.07).
CONCLUSION: Receipt of biologics in older adults with rheumatoid arthritis increased over a period of time when insurance coverage was expanded without increasing patients' out-of-pocket costs. During this time period, concurrent improvements in self-reported health status and functional status suggest improved arthritis care.
Source
Am J Med. 2012 Sep;125(9):937.e9-15. doi: 10.1016/j.amjmed.2011.11.014. Epub 2012 Jun 9. Link to article on publisher's site