IL-6 boosts synaptogenesis STAT!
Faust, Travis E ; Schafer, Dorothy P
Faust, Travis E
Schafer, Dorothy P
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UMass Chan Affiliations
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Journal Article
Publication Date
2021-11-09
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Abstract
Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Source
Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. Link to article on publisher's site
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DOI
10.1016/j.immuni.2021.10.010
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PubMed ID
34758335