Publication

IL-6 boosts synaptogenesis STAT!

Faust, Travis E
Schafer, Dorothy P
Citations
Altmetric:
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2021-11-09
Subject Area
Embargo Expiration Date
Abstract

Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.

Source

Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. Link to article on publisher's site

Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1016/j.immuni.2021.10.010
PubMed ID
34758335
Other Identifiers
Notes
Funding and Acknowledgements
Corresponding Author
Related Resources
Related Resources
Repository Citation
Rights
Distribution License