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Cancer targeting using tumor suppressor genes

Chada, Sunil
Menander, Kerstin B.
Bocangel, Dora B.
Roth, Jack A.
Ramesh, Rajagopal
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Journal Article
Publication Date
2007-11-06
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Abstract

Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drugs that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

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Front Biosci. 2008 Jan 1;13:1959-67.

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17981683
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