Whole blood gene expression and atrial fibrillation: the Framingham Heart Study
Lin, Honghuang Yin, Xiaoyan Lunetta, Kathryn L. Dupuis, Josee McManus, David D Lubitz, Steven A. Magnani, Jared W. Joehanes, Roby Munson, Peter J. Larson, Martin G.
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Abstract
BACKGROUND: Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF.
METHODS AND RESULTS: We performed genome-wide whole blood transcriptomic profiling (Affymetrix Human Exon 1.0 ST Array) of 2446 participants (mean age 66 +/- 9 years, 55% women) from the Offspring cohort of Framingham Heart Study. The study included 177 participants with prevalent AF, 143 with incident AF during up to 7 years follow up, and 2126 participants with no AF. We identified seven genes statistically significantly up-regulated with prevalent AF. The most significant gene, PBX1 (P = 2.8 x 10(-7)), plays an important role in cardiovascular development. We integrated differential gene expression with gene-gene interaction information to identify several signaling pathways possibly involved in AF-related transcriptional regulation. We did not detect any statistically significant transcriptomic associations with incident AF.
CONCLUSION: We examined associations of gene expression with AF in a large community-based cohort. Our study revealed several genes and signaling pathways that are potentially involved in AF-related transcriptional regulation.
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PLoS One. 2014 May 7;9(5):e96794. doi: 10.1371/journal.pone.0096794. Link to article on publisher's site