The inaugural 2022 HRX meeting (HRX22) was sponsored by the Heart Rhythm Society (HRS). In 2019, in alignment with HRS’s strategic plan to innovate to improve patient care and expand digital health and after launching the Cardiovascular Digital Health Journal, HRS planned to annually convene all stakeholders to accelerate cardiovascular innovation. The HRX22 meeting focused on innovation in digital health. Unlike other digital health summits, HRX22 brought together the entire spectrum of stakeholders, including cardiovascular clinicians; engineers; product developers; entrepreneurs; investors; hospital administrators; medical technology, commercial technology, and pharmaceutical companies; regulators; nonprofit organizations; and patient advocacy groups to develop patient-centered digital solutions to many of the challenges of the current healthcare environment. The meeting was designed to be small, and it took place in a single and “intimate” conference room with 1 central stage in San Diego, California, in September of 2022, and was enabled by digital tools for presentations and interactions. The meeting was attended by almost 600 participants—the target for the inaugural HRX event. In addition to main tent sessions, fireside chats, crash courses, and roundtable discussions, the meeting included abstract presentations showcasing innovative digital health research and a pitch competition for innovators with premarket development ideas. Some of the important topics discussed at the meeting are shown in Figure 1. This paper highlights the main discussions that occurred at the meeting.