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    Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells

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    Authors
    Nishinaga, Hiromi
    Takahashi-Niki, Kazuko
    Taira, Takahiro
    Andreadis, Athena
    Iguchi-Ariga, Sanai M. M.
    Ariga, Hiroyoshi
    UMass Chan Affiliations
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2005-08-24
    Keywords
    Amino Acid Substitution
    Animals
    Gene Expression Regulation
    Gene Silencing
    Mice
    Mutation
    NIH 3T3 Cells
    Oncogene Proteins
    Structure-Activity Relationship
    Superoxide Dismutase
    tau Proteins
    Cell Biology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.neulet.2005.07.053
    Abstract
    DJ-1 is a novel oncogene and a causative gene for the familial form of Parkinson's disease (PD). DJ-1 has been shown to play roles in anti-oxidative stress by eliminating reactive oxygen species and in transcriptional regulation of genes. Loss of these functions of DJ-1 is thought to trigger the onset of PD. In this study, to identify genes for which expressions are regulated by DJ-1, DNA microarray analyses were carried out using two mouse NIH3T3 cell lines, DJ-1-knockdown cells and cells harboring an exogenously added L 166 P DJ-1 mutant found in PD patients. In both cell lines, drastic changes in expressions of genes, including genes related to stress, apoptosis, oxidative stress and neurotoxicity, were observed and changes in expressions were confirmed by RT-PCR. Of the genes identified, expression level of the extracellular superoxide dismutase (SOD 3) gene was found to decrease in DJ-1-knockdown cells, while expressions of SOD 1 and SOD 2 genes did not change. Furthermore, expression of the tau gene, a gene whose product gives cells neurotoxicity by aggregation, was found to increase at its promoter level in L 166 P DJ-1 cells. These findings suggest that DJ-1 regulates expressions of genes for which functions are thought to be related to cell death or neurodegeneration.
    Source
    Neurosci Lett. 2005 Dec 16;390(1):54-9. Link to article on publisher's site
    DOI
    10.1016/j.neulet.2005.07.053
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/25675
    PubMed ID
    16115732
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neulet.2005.07.053
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