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Transcriptional regulation of the mouse microtubule-associated protein tau

dc.contributor.authorGao, Lei
dc.contributor.authorTucker, Kerry L.
dc.contributor.authorAndreadis, Athena
dc.date2022-08-11T08:07:57.000
dc.date.accessioned2022-08-23T15:37:16Z
dc.date.available2022-08-23T15:37:16Z
dc.date.issued2005-01-04
dc.date.submitted2010-09-30
dc.identifier.citationBiochim Biophys Acta. 2005 Jan 11;1681(2-3):175-81. Epub 2004 Nov 26. <a href="http://dx.doi.org/10.1016/j.bbaexp.2004.10.008">Link to article on publisher's site</a>
dc.identifier.issn0006-3002 (Linking)
dc.identifier.doi10.1016/j.bbaexp.2004.10.008
dc.identifier.pmid15627509
dc.identifier.urihttp://hdl.handle.net/20.500.14038/25679
dc.description.abstractThe microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a approximately 7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15627509&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.bbaexp.2004.10.008
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectGene Expression Regulation
dc.subjectHumans
dc.subjectMice
dc.subjectMicrotubules
dc.subjectMolecular Sequence Data
dc.subjectPromoter Regions, Genetic
dc.subjectRats
dc.subjectSequence Alignment
dc.subjectTranscription, Genetic
dc.subjecttau Proteins
dc.subjectCell Biology
dc.titleTranscriptional regulation of the mouse microtubule-associated protein tau
dc.typeJournal Article
dc.source.journaltitleBiochimica et biophysica acta
dc.source.volume1681
dc.source.issue2-3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/andreadis/15
dc.identifier.contextkey1587272
html.description.abstract<p>The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a approximately 7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.</p>
dc.identifier.submissionpathandreadis/15
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages175-81


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