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    A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans

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    Authors
    Tang, Wen
    Seth, Meetu
    Tu, Shikui
    Shen, En-Zhi
    Li, Qian
    Shirayama, Masaki
    Weng, Zhiping
    Mello, Craig C.
    UMass Chan Affiliations
    Program in Bioinformatics and Integrative Biology
    RNA Therapeutics Institute
    Document Type
    Journal Article
    Publication Date
    2018-03-26
    Keywords
    Caenorhabditis briggsae
    Caenorhabditis elegans
    dosage compensation
    piRNAs
    sex determination
    small RNAs
    Biochemistry, Biophysics, and Structural Biology
    Bioinformatics
    Computational Biology
    Developmental Biology
    
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    Link to Full Text
    https://doi.org/10.1016/j.devcel.2018.01.025
    Abstract
    In metazoans, Piwi-related Argonaute proteins engage piRNAs (Piwi-interacting small RNAs) to defend the genome against invasive nucleic acids, such as transposable elements. Yet many organisms-including worms and humans-express thousands of piRNAs that do not target transposons, suggesting that piRNA function extends beyond genome defense. Here, we show that the X chromosome-derived piRNA 21ux-1 downregulates XOL-1 (XO Lethal), a master regulator of X chromosome dosage compensation and sex determination in Caenorhabditis elegans. Mutations in 21ux-1 and several Piwi-pathway components sensitize hermaphrodites to dosage compensation and sex determination defects. We show that the piRNA pathway also targets xol-1 in C. briggsae, a nematode species related to C. elegans. Our findings reveal physiologically important piRNA-mRNA interactions, raising the possibility that piRNAs function broadly to ensure robust gene expression and germline development.
    Source

    Dev Cell. 2018 Mar 26;44(6):762-770.e3. doi: 10.1016/j.devcel.2018.01.025. Epub 2018 2018 Feb 15. Link to article on publisher's site

    DOI
    10.1016/j.devcel.2018.01.025
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/25837
    PubMed ID
    29456136
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    ae974a485f413a2113503eed53cd6c53
    10.1016/j.devcel.2018.01.025
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